The effects of 13 weeks of liraglutide treatment on endocrine and 1 exocrine pancreas in male and female ZDF - rats 2 – A quantitative and qualitative analysis revealing no evidence of 3 drug induced pancreatitis
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چکیده
The effects of 13 weeks of liraglutide treatment on endocrine and 1 exocrine pancreas in male and female ZDF-rats 2 – A quantitative and qualitative analysis revealing no evidence of 3 drug induced pancreatitis 4 5 Running head: Liraglutide does not induce pancreatitis in the ZDF rat 6 7 *Niels Vrang,* Jacob Jelsing, *Lotte Simonsen, Andres Eskjær Jensen, Inger 8 Thorup, Henrik Søeborg and Lotte Bjerre Knudsen 9 10 *Authors contributing equally to this work 11 12 Gubra ApS, Agern Allé 1, 2970 Hørsholm, Denmark 13 Pharmacology Management, Novo Nordisk A/S, Denmark 14 Diabetes Pharmacology – Type 2 Diabetes, Novo Nordisk A/S, Denmark 15 Pathology, Novo Nordisk A/S, Denmark 16 17 Number of figures: 8 18 Number of Tables: 2 19 20 Corresponding author: 21 Lotte Bjerre Knudsen, Novo Nordisk, Novo Nordisk Park, DK-2760 Maaloev, 22 Denmark, +45 3075 4788, [email protected] 23 24
منابع مشابه
The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis.
A possible association between glucagon-like peptide-1 (GLP-1) analogs and incidences of pancreatitis has been suggested based on clinical studies. In male and female diabetic Zucker diabetic fatty (ZDF) rats, we investigated the effects of continuous administration of liraglutide and exenatide on biochemical [lipase, pancreatic amylase (P-amylase)] and histopathological markers of pancreatitis...
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Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-like peptide-1 (GLP-1) receptor agonists. In a 52-week study with liraglutide, a ...
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Background: Chronic pancreatitis is a progressive fibrosis of the pancreas that leads to loss of endocrine and exocrine function of pancreas. The most common symptom is intractable pain. Which adversely effects quality of life, remains the most common indication for surgery in patients with chronic pancreatitis. Case report: Three patients underwent operations for chronic pancreatitis at the ...
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Introduction: The preventive antidiabetic effects of garlic juice on blood glucose levels and pancreas tissue was evaluated in STZ-induced diabetic rats. Methods: 40 male rats were divided into five groups of 8 rats each. 1) Normal group (N), 2) Normal+Garlic group (N+G) received 1 ml garlic juice/100g BW/day for 6 weeks, 3) Diabetic group (D) injected with streptozotocin (60 mg/kg BW,i.p.), 4)...
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I , on behalf of Butler et al. (1), thank Bjerre Knudsen et al. (2) for their comments and accept their statement that liraglutide was not withdrawn before euthanasia of the monkeys. Nyborg et al. (3) reported routine pathological examination in the pancreas of young healthy members of three species. A single transverse section of the midpart of the pancreas was stained with hematoxylin and eos...
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